Adipose tissue macrophages in non-rodent mammals: a comparative study.
Identifieur interne : 000052 ( Main/Exploration ); précédent : 000051; suivant : 000053Adipose tissue macrophages in non-rodent mammals: a comparative study.
Auteurs : Grace Ampem [Allemagne] ; Hind Azegrouz [États-Unis] ; Árpád Bacsadi [Hongrie] ; Lajos Balogh [Hongrie] ; Susanne Schmidt [Allemagne] ; Julianna Thur Czy [Hongrie] ; Tamás Röszer [Allemagne]Source :
- Cell and tissue research [ 1432-0878 ] ; 2016.
English descriptors
- KwdEn :
- Acid Phosphatase (metabolism), Adipose Tissue (cytology), Animals, Biomarkers (metabolism), Cell Shape, Female, Immunophenotyping, Isoenzymes (metabolism), Lysosomal-Associated Membrane Protein 2 (metabolism), Macrophages (cytology), Macrophages (enzymology), Macrophages (ultrastructure), Male, Mammals (metabolism), Obesity (pathology), Phenotype, Rodentia, Tartrate-Resistant Acid Phosphatase.
- MESH :
- chemical , metabolism : Acid Phosphatase, Biomarkers, Isoenzymes, Lysosomal-Associated Membrane Protein 2.
- cytology : Adipose Tissue, Macrophages.
- enzymology : Macrophages.
- metabolism : Mammals.
- pathology : Obesity.
- ultrastructure : Macrophages.
- Animals, Cell Shape, Female, Immunophenotyping, Male, Phenotype, Rodentia, Tartrate-Resistant Acid Phosphatase.
Abstract
The stromal vascular fraction (SVF) of adipose tissue in rodents and primates contains mesenchymal stem cells and immune cells. SVF cells have complex metabolic, immune and endocrine functions with biomedical impact. However, in other mammals, the amount of data on SVF stem cells is negligible and whether the SVF hosts immune cells is unknown. In this study, we show that the SVF is rich in immune cells, with a dominance of adipose tissue macrophages (ATMs) in cattle (Bos primigenius taurus), domestic goat (Capra aegagrus hircus), domestic sheep (Ovis aries), domestic cat (Felis catus) and domestic dog (Canis familiaris). ATMs of these species are granulated lysosome-rich cells with lamellipodial protrusions and express the lysosome markers acid phosphatase 5 (ACP-5) and Mac-3/Lamp-2. Using ACP-5 and Mac-3/Lamp-2 as markers, we additionally detected ATMs in other species, such as the domestic horse (Equus ferus caballus), wild boar (Sus scrofa) and red fox (Vulpes vulpes). Feline and canine ATMs also express the murine macrophage marker F4/80 antigen. In the lean condition, the alternative macrophage activation marker CD206 is expressed by feline and canine ATMs and arginase-1 by feline ATMs. Obesity is associated with interleukin-6 and interferon gamma expression and with overt tyrosine nitration in both feline and canine ATMs. This resembles the obesity-induced phenotype switch of murine and human ATMs. Thus, we show, for the first time, that the presence of ATMs is a general trait of mammals. The interaction between the adipose cells and SVF immune cells might be evolutionarily conserved among mammals.
DOI: 10.1007/s00441-015-2253-1
PubMed: 26239911
Affiliations:
- Allemagne, Hongrie, États-Unis
- Bade-Wurtemberg, District de Tübingen, Hongrie centrale
- Budapest, Ulm
- Université d'Ulm
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Le document en format XML
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Szent István University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Roszer, Tamas" sort="Roszer, Tamas" uniqKey="Roszer T" first="Tamás" last="Röszer">Tamás Röszer</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Comparative Molecular Endocrinology, University of Ulm, Ulm, Germany. tamas.roeszer@uni-ulm.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Comparative Molecular Endocrinology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author></analytic><series><title level="j">Cell and tissue research</title><idno type="eISSN">1432-0878</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acid Phosphatase (metabolism)</term><term>Adipose Tissue (cytology)</term><term>Animals</term><term>Biomarkers (metabolism)</term><term>Cell Shape</term><term>Female</term><term>Immunophenotyping</term><term>Isoenzymes (metabolism)</term><term>Lysosomal-Associated Membrane Protein 2 (metabolism)</term><term>Macrophages (cytology)</term><term>Macrophages (enzymology)</term><term>Macrophages (ultrastructure)</term><term>Male</term><term>Mammals (metabolism)</term><term>Obesity (pathology)</term><term>Phenotype</term><term>Rodentia</term><term>Tartrate-Resistant Acid Phosphatase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Acid Phosphatase</term><term>Biomarkers</term><term>Isoenzymes</term><term>Lysosomal-Associated Membrane Protein 2</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Adipose Tissue</term><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mammals</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Macrophages</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Shape</term><term>Female</term><term>Immunophenotyping</term><term>Male</term><term>Phenotype</term><term>Rodentia</term><term>Tartrate-Resistant Acid Phosphatase</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The stromal vascular fraction (SVF) of adipose tissue in rodents and primates contains mesenchymal stem cells and immune cells. SVF cells have complex metabolic, immune and endocrine functions with biomedical impact. However, in other mammals, the amount of data on SVF stem cells is negligible and whether the SVF hosts immune cells is unknown. In this study, we show that the SVF is rich in immune cells, with a dominance of adipose tissue macrophages (ATMs) in cattle (Bos primigenius taurus), domestic goat (Capra aegagrus hircus), domestic sheep (Ovis aries), domestic cat (Felis catus) and domestic dog (Canis familiaris). ATMs of these species are granulated lysosome-rich cells with lamellipodial protrusions and express the lysosome markers acid phosphatase 5 (ACP-5) and Mac-3/Lamp-2. Using ACP-5 and Mac-3/Lamp-2 as markers, we additionally detected ATMs in other species, such as the domestic horse (Equus ferus caballus), wild boar (Sus scrofa) and red fox (Vulpes vulpes). Feline and canine ATMs also express the murine macrophage marker F4/80 antigen. In the lean condition, the alternative macrophage activation marker CD206 is expressed by feline and canine ATMs and arginase-1 by feline ATMs. Obesity is associated with interleukin-6 and interferon gamma expression and with overt tyrosine nitration in both feline and canine ATMs. This resembles the obesity-induced phenotype switch of murine and human ATMs. Thus, we show, for the first time, that the presence of ATMs is a general trait of mammals. The interaction between the adipose cells and SVF immune cells might be evolutionarily conserved among mammals.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Hongrie</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>District de Tübingen</li><li>Hongrie centrale</li></region><settlement><li>Budapest</li><li>Ulm</li></settlement><orgName><li>Université d'Ulm</li></orgName></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Ampem, Grace" sort="Ampem, Grace" uniqKey="Ampem G" first="Grace" last="Ampem">Grace Ampem</name></region><name sortKey="Roszer, Tamas" sort="Roszer, Tamas" uniqKey="Roszer T" first="Tamás" last="Röszer">Tamás Röszer</name><name sortKey="Schmidt, Susanne" sort="Schmidt, Susanne" uniqKey="Schmidt S" first="Susanne" last="Schmidt">Susanne Schmidt</name></country><country name="États-Unis"><noRegion><name sortKey="Azegrouz, Hind" sort="Azegrouz, Hind" uniqKey="Azegrouz H" first="Hind" last="Azegrouz">Hind Azegrouz</name></noRegion></country><country name="Hongrie"><noRegion><name sortKey="Bacsadi, Arpad" sort="Bacsadi, Arpad" uniqKey="Bacsadi A" first="Árpád" last="Bacsadi">Árpád Bacsadi</name></noRegion><name sortKey="Balogh, Lajos" sort="Balogh, Lajos" uniqKey="Balogh L" first="Lajos" last="Balogh">Lajos Balogh</name><name sortKey="Thur Czy, Julianna" sort="Thur Czy, Julianna" uniqKey="Thur Czy J" first="Julianna" last="Thur Czy">Julianna Thur Czy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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